Absorption of pivampicillin in postoperative patients.
نویسندگان
چکیده
The absorption of orally administered pivampicillin was studied in nine postoperative patients and compared with that of intravenously administered ampicillin. The absorption of pivampicillin was calculated on the basis of comparison of the areas under the serum concentration curves for both modes of administration. After an oral dose of 700 mg the absorption ranged from 40 to 95% (mean, 60%).
منابع مشابه
Antimicrobial Agents and Chemotherapy.
Despite its relatively good acid stability, ampicillin is absorbed rather poorly from the gastro-intestinal tract, varying from 30 to 50% (8, 10, 12). One of the attempts to achieve better absorption resulted in the development of pivampicillin, the pivaloyloxymethyl ester of ampicillin, which is rapidly hydrolyzed to ampicillin in the body; 15 min after administration, more than 99% of the dru...
متن کاملTriple crossover study on absorption and excretion of ampicillin, pivampicillin, and amoxycillin.
The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicillin was given with breakfast. The mean half-life times were nearly identical fo...
متن کاملPharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin.
Bacampicillin, a new oral prodrug which in vivo is rapidly transformed to ampicillin, was compared with ampicillin, pivampicillin, and amoxycillin in a randomized cross-over study on 11 healthy volunteers. All drugs were given in oral doses equimolar to 400 mg of bacampicillin (800 mumol). The mean of the individual peak concentrations in serum was 8.3 mug/ml for bacampicillin, 7.1 mug/ml for p...
متن کاملClinical pharmacology of pivampicillin.
Studies on pivampicillin hydrochloride and ampicillin trihydrate, administered in capsules to healthy volunteers, indicated that pivampicillin was absorbed more efficiently from the gastrointestinal tract than ampicillin. Average peak concentrations of ampicillin in the serum after doses equimolar to 250 mg of ampicillin were 6.8 mug/ml at 56 min with pivampicillin and 1.96 mug/ml at 1 h 24 min...
متن کاملPivampicillin HCl-probenecid combination in the treatment of uncomplicated gonorrhoea.
A new semisynthetic oral penicillin, pivampicillin HCG, is rapidly hydrolysed to ampicillin in the body. Because of efficient absorption from the gastrointestinal tract, it is reported to give serum concentrations considerably higher than those obtained with a corresponding dose of ampicillin (Frederiksen, Godtfredsen, Nielsen, and Roholt, 1971). A previous study (F6rstrom and Lassus, 1972) sho...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 8 1 شماره
صفحات -
تاریخ انتشار 1975